PDB.1HHO
NB-IRON-07
FORTIFICATIONIron-dense protein bar
Heme-mimic fold that chelates Fe²⁺ from leafy inputs. Animal-source bioavailability, zero animal.
What we build[ 1 / 6 ]
Nutrition,
designed from scratch.
Null Bites is a biocomputation company building nutrition products. We write novel food-grade proteins from first principles, then turn them into things you can eat.
The thesis[ 2 / 6 ]
AlphaFold cracked protein structure in 2020. Billions went to pharma. Nutrition got nothing.
Nutrition is protein engineering. Meat texture comes from myosin and collagen. Eggs set because of ovalbumin. Cheese stretches because of casein. Every property you care about in food traces back to the shape and behaviour of a specific protein.
The tools that design drug molecules can design food molecules. The infrastructure to do it at scale exists because we built it. ProteinMPNN and ESMFold, stitched into an autonomous loop that reads papers, generates sequences, runs simulations, scores every candidate against real constraints, and iterates on its own.
Our designs don't stop at a .pdb file. Each top candidate goes to the bench, into a fermenter, and out the other side as an ingredient formulated into a real product. Performance, recovery, fortification, gut health, plant-based whole foods. The benchmark is simple: you pick it up, you bite into it.
Ignored for
5 years
Since AlphaFold 2, every computational biology dollar chased therapeutics.
Agriculture uses
70%
…of global freshwater. And still can’t scale to 10B people.
The loop[ 3 / 6 ]
Meet the autonomous scientist.
It runs experiments, scores its own results, and only the designs a human would trust make it to the bench. Everything that follows ends in a thing you can eat.
01
The AI runs experiments
An autonomous scientist reads every new paper, writes new amino-acid sequences, and never sleeps.
02
We score, it re-scores itself
Every candidate folded in silico and stress-tested. A self-critic throws out 99% as too optimistic.
03
Top designs go to the bench
The survivors are ordered as DNA, expressed in bacteria, purified, and handed to a human food scientist.
04
A product you can eat
Formulated, sensory-panelled, shipped. The only benchmark that counts is a person taking a bite.
Under the hoodclick to expand
01IngestLLM · autonomous reader
1,400+ papers parsed into a living corpus of functional motifs, substrate bindings, and known dead-ends. The reader never sleeps and never forgets a result.
02DesignProteinMPNN · RFdiffusion
Novel amino-acid sequences generated against a target fold with a bundle of functional constraints: heat stability, water solubility, fibre alignment, binding pocket geometry.
03Fold and scoreESMFold · AF-Multimer
Every sequence is folded in silico, then scored on stability, manufacturability, and nutritional fit. The pipeline throws out anything without a clear physical basis.
04Self-critiqueRe-read · re-rank · drop
146 cycles of self-correction. The system reads its own output and drops candidates that look too confident. Designs that survive cycle 140+ get to the bench.
05BenchGene synthesis · E.coli
Top candidates are ordered as DNA from a synthesis vendor, expressed in bacteria, purified, and handed to the formulation team.
06ProductFormulate · sensory · ship
The ingredient becomes food. Sensory panels with real people. If it passes, it ships. If it fails, the result goes back to the top of the loop.
The products[ 4 / 6 ]
Five proteins going to market. None of them existed a year ago.
Each candidate is a novel sequence, folded in silico, synthesized at the bench, and formulated into a product with a specific job.
PDB.2MYS
NB-FIBRE-03
PLANT-BASED MEATFibrous whole-muscle analogue
Long coiled-coil engineered to self-assemble into aligned fibres under shear. The missing chew.
PDB.1OVA
NB-GEL-02
EGG REPLACEMENTHeat-set bake gel
Ovalbumin-inspired scaffold tuned for lower set temps. Gels like egg, without touching a hen.
+ 2 more products in queue · Performance · recovery · gut-health · plant-based whole food
Open by default[ 5 / 6 ]
The first nutrition-products company run in the open.
Every sequence, every score, every failed synthesis. Published within 48 hours. Forkable. Falsifiable. The product margins are ours. The science isn't.
Pharma kept its wins private and its failures private too. Food is too important for that. Open the science, ship the product, let anyone build the next one.
null-bites/pipeline · main
live feed- 2m ago7ab91f2design
NB-IRON-07: dock score improved −11.3 → −12.1
- 14m agoe4c3a88critic
pipeline: self-critic caught over-confidence on fold #146
- 1h agoc10b05dsim
NB-FIBRE-03: simulation @ shear rate 500s⁻¹ — stable
- 3h ago0ff22a4ingest
ingest: 17 new papers from NeurIPS bio-track
- 6h ago9ae8721design
NB-GEL-02: Tm reduced 72 → 65°C after redesign
- 9h ago3d7c5a1synth
bench: gene synthesis order placed for NB-IRON-07
- 12h agob12fe09data
dataset: OpenBio-Nutrition v0.3 pushed
Get in touch[ 6 / 6 ]
Manufacturing with us.
Eating with us.
Investing in us.
founders@nullbites.comTypical reply in 24h · Bangalore + SFO